Brain-computer interface (BCI) is an emerging technology from different disciplines, including neuroscience, computer science and biomedical engineering. This makes it possible to directly communicate human brain with external environment and manipulate the devices without the muscles and peripheral nervous system, which could provide a new pathway for some patients with neural damage. In the development of BCI, researchers can category the BCI according to the method of recording the brain activity, for example, the technology based on electrical signal, including the Electroencephalography (EEG), and the technology on the blood dynamics, including fMRI and NIRS. Here, we mainly focus on developing some BCI system and related technology based on near infrared reflectance spectroscopy (NIRS). NIRS is a non-invasive and portable technology, which can be used in some clinical application. Currently, we are exploring a new technology, that is, responsive brain computer interface based on near infrared reflectance spectroscopy. We hope that it can be helpful for some patients with severe brain damage to communicate with external environment.